Hampshire was born in Montreal, Quebec. She is most widely known to international audiences for her role as Angelina to Sean Astin's Michael in the 1998 romantic comedy Boy Meets Girl, and Vivienne in the 2006 film Snow Cake, in which she starred opposite Sigourney Weaver and Alan Rickman.
Having been professionally active in the Canadian film and TV industry since 1996, Hampshire is also notable for her role as Siobhan Roy on Made in Canada. More recently, she has starred in the Canadian series This Space For Rent, Carl² and Northern Town. She also starred alongside Kevin Zegers and Samaire Armstrong in the 2006 romantic comedy It's a Boy/Girl Thing, in which she played the character Chanel. She played Margaret in The Life Before This, a feature film directed by Jerry Ciccoritti, which premiered at the Toronto International Film Festival in 1999. She also voiced Starr/Nebula on the animated Canadian sitcom 6Teen. Most recently, she appeared in The Trotsky as Leon's love interest Alexandra, in the Canadian indie film, Good Neighbours as Louise, and in David Cronenberg's Cosmopolis as Jane Melman.
Hampshire has won a Gemini Award in Best Ensemble Performance in a Comedy Program or Series for Made in Canada.
She has thrice been nominated for Canadian Genie Awards. She was a Best Supporting Actress nominee at the 24th Genie Awards for the movie A Problem with Fear, a Best Leading Actress nominee at the 25th Genie Awards for the movie Blood, and a Best Supporting Actress nominee at the 27th Genie Awards for the movie Snow Cake.
|1998||Boy Meets Girl||Angelina Milleflores|
|1999||The Life Before This||Margaret|
|2003||In Shadow||Lydia||Short film|
|2003||A Problem with Fear||Dot|
|2006||Snow Cake||Vivienne Freeman|
|2006||Couldn't Be Happier||Jessica Cornwall||Short film|
|2006||It's a Boy Girl Thing||Chanel|
|2009||The Trotsky||Alexandra Leith|
|2010||What's the Harm?||Marlee||Short film|
|2012||My Awkward Sexual Adventure||Julia Bowe|
|2013||All the Wrong Reasons||Nicole||Post-production|