Hume modeled for Dior, Givenchy, Chanel, Lanvin, Yves Saint Laurent, Christian Lacroix, Gianfranco Ferré, Claude Montana, Alexander McQueen, Giorgio Armani, Gianni Versace, Roberto Cavalli, Prada, Calvin Klein, Ralph Lauren, Oscar de la Renta and Donna Karan, among other leading designers and brands. She also frequently appeared on the covers of Harper's Bazaar, photographed by Patrick Demarchelier, as well as Vogue, W and other publications.
In 1996 Hume was the feature model for Chanel ads. She has modelled for Victoria's Secret. For the March 1996 Gucci presentation of fall and winter fashion collections in Milan, Italy, Hume wore a dress made of white jersey (clothing) with a plunging neckline.
Following a 1997 Paris, France showing of Karl Lagerfeld designs for Chanel, Hume was queried by a Russian TV reporter. He asked her what was the most exciting part of her job. She answered, Um, the money. She appeared in a bias-cut chiffon gown designed by Donatella Versace at the January 1998 Milan fashion show.
She is married to rocker and actor Donovan Leitch, Jr.. After getting married in Scotland in 1997, they drove all around Bali in a jeep. The couple have a daughter named Violet, born March 2004.
Hume attended a Halloween party at Lot 61 in Chelsea, Manhattan, with Leitch and Oliver Stone, in 1998. The Japanese-themed event included an appearance byLeonardo DiCaprio and friends dressed as members of Kiss. Hume arrived in fangs. The night before Halloween in 1999 Leitch and Hume hosted a party at the same venue. Hume was draped in vines and the couple were scantily dressed as Adam and Eve.
She also starred in an interactive fashion art film by Imagine Fashion called, "Decadent Control" with Roberto Cavalli, Eva Herzigová, and Brad Kroenig. The film features fashion from Agent Provocateur and H&Mand premiered in March 2011.