I'Anson was a presenter on BBC Radio 1 from 1995 until 1999. In January 1995 she took over the Lunchtime show from 12 to 2pm from Emma Freud, which she continued to present until going on maternity leave at Christmas 1996. When she returned from leave in April 1997, she was moved to weekend afternoons from 12.30 to 3pm, her weekday lunchtime show having been taken by Jo Whiley. I'Anson presented her last show for Radio 1 on 21 February 1999, the following week she was replaced byEmma B. She had been sacked after failing to show up for a show after going missing after clubbing in Ibiza. A quote from Simone who was working for MTV at the time "Lisa was meant to do a live BBC radio show from the island, but never showed up. So what happened in those missing hours???? Let's just say that things got slightly out of hand at the infamous Manumission Motel". Ian Parkinson, Radio 1's head of specialist music programmes, puts it another way: "There had been tabloid accusations of us being closely linked to Manumission, where sex is openly promoted on stage...But then we lost Lisa I'Anson in Manumission - later found in a less than coherent state.".
I'Anson first found fame on MTV Europe reading the music news back in the 1990s. In the following years, her work included multiple programs and shows. On MTV I'Anson was a VJ (media personality) for 6 years presenting such shows as MTV News and the nightly live weekday show Hanging Out. Later on she was also presenting other live TV shows including the very first and subsequent MOBO awards (music of black origin), The Freddie Mercury Tribute Concert at Wembley Stadium and a live link from Ghana, West Africa direct to London with then British Prime Minister and U.S. President, Tony Blair and Bill Clinton. I'Anson also fronted her own agony aunt show Dear Dilemma for BBC 2 and also presented shows for Top of the Pops, the United Kingdom's longest running weekly music show. Furthermore I'Anson narrated numerous television shows including the notorious Ibiza Uncovered for Sky One.
In 2005, I'Anson was a housemate in Celebrity Big Brother 3 On January 19 she left the show as the third person being evicted. In 2007 she took part in ITV2's Deadline with chief editor Janet Street Porter with followed ten celebrities as they aimed to write, edit and produce a celebrity based magazine, which was published as a supplement in Closer magazine.
Between 2002 and 2004, I'Anson was the narrator of the Uncovered series beginning with Ibiza Uncovered I ITV's Club Reps. In 2006, she was heard as the voice of Vernon Kay's revival of Family Fortunes. As an experienced voice-over artist, today I'Anson is frequently voicing in commercials and television documentaries. I'Anson formerly co-managed the girl band Honeyshot.