Her family's Greek ancestral village is in Sekhia and the family name is Anastasakis.
After finishing her degree in psychology at the Victoria University of Manchester in 1995, Nemone worked as a research assistant in a psychiatric ward. She thereafter realised her career interest to be inbroadcasting.
She began modestly on reception and while still manning the phones daily at Kiss 102 in Manchester. In 1997, she became the presenter and producer of The Word radio programme as radio station Kiss 105went on the air. After that, she presented Galaxy 102 FM's Morning Show, Network Chill Out Show and The Galaxy Chart for Manchester. Having joined the station manning reception, she left three years later anchor of the Morning Show heading to London to a job at BBC Radio 1.
Nemone joined BBC Radio 1 in October 2000 initially hosting the Saturday breakfast show. She filled in for Jo Whiley's weekday morning show for many months in 2001 while Whiley was on maternity leave. In light of that, Nemone was then awarded the weekend afternoon slot which she hosted from Autumn 2001 through to the end of 2003.
After a high profile revamp of the Radio 1 daytime schedule from early 2004, Nemone replaced Scott Mills on the overnight show (4am–7am) broadcasting to audiences in excess of 3 million. She left Radio 1 in September 2005, and the slot was taken by JK and Joel (Monday-Thursday) and Fearne and Reggie (Friday) took over her early morning slot.
Cerys Matthews filled in for Nemone on BBC Radio 6 Music after she began six months maternity leave on 6 July 2009. After Matthews herself went on maternity leave on 24 November, the show was then presented by either Chris Hawkins or Andrew Collins. In July 2009, Nemone gave birth to a baby girl and returned to BBC 6 Music on 1 February 2010
With the imminent arrival of her second child in 2011, she moved from weekdays taking over the reigns of the weekend breakfast show. After a short maternity leave she returned, steering it to record RAJAR figures.
The requirement to take the show to Media City in Salford meant Nemone passing on the opportunity of returning to Manchester; electing to stay in London where she had established her young family.
In April 2013 Nemone fulfilled an lifelong ambition to curate a specialist dance and electronic music show on BBC Radio 6 Music - Nemone's Electric Ladyland. In addition, she runs a club night in West London - Sounds Perfect presents Way Out West
She participated with her daughter in the Bumps & Babies Mile in Battersea Park for Sport Relief 2010 along with Denise Van Outen, Carly Cole, Gail Emms, Natasha Kaplinsky and Kim Medcalf.
Nemone co-hosted the BBC One television programme 101 Ways to Leave a Gameshow alongside Steve Jones. She was seen describing the method of eviction from the game show and then interviewing the losing contestants.
Nemone is an accomplished musician. She was singer and saxophonist in a funk band - other members being Tom Findlay (who went on to form Groove Armada), Andy Spence from NYPC, and Perrier Award winning comedian Dan Antopolski.
Apart from radio and TV broadcasting, Nemone is also a keen athlete.
Nemone is a former champion 400 metres runner. In 1999 she won the Greater Manchester Championships. In 2000 she qualified for the British Championships, and competed in the 400m British Olympic trials.
She has competed in triathlons, most notably finishing in the top 20 amateur women in the 2006 London Triathlon.